.fs-8{font-size:.5rem;line-height:.6875rem}.fs-8 sup{font-size:.3333333333rem;top:-.1666666667rem}.fs-10{font-size:.625rem;line-height:.859375rem}.fs-10 sup{font-size:.4166666667rem;top:-.2083333333rem}.fs-12{font-size:.75rem;line-height:1.03125rem}.fs-12 sup{font-size:.5rem;top:-.25rem}.fs-14{font-size:.875rem;line-height:1.203125rem}.fs-14 sup{font-size:.5833333333rem;top:-.2916666667rem}.fs-16{font-size:1rem;line-height:1.375rem}.fs-16 sup{font-size:.6666666667rem;top:-.3333333333rem}.fs-18{font-size:1.125rem;line-height:1.546875rem}.fs-18 sup{font-size:.75rem;top:-.375rem}.fs-20{font-size:1.25rem;line-height:1.71875rem}.fs-20 sup{font-size:.8333333333rem;top:-.4166666667rem}.fs-24{font-size:1.5rem;line-height:2.0625rem}.fs-24 sup{font-size:1rem;top:-.5rem}.fs-30{font-size:1.875rem;line-height:2.578125rem}.fs-30 sup{font-size:1.25rem;top:-.625rem}.fs-36{font-size:2.25rem;line-height:3.09375rem}.fs-36 sup{font-size:1.5rem;top:-.75rem}.fs-40{font-size:2.5rem;line-height:3.4375rem}.fs-40 sup{font-size:1.6666666667rem;top:-.8333333333rem}.fs-48{font-size:3rem;line-height:4.125rem}.fs-48 sup{font-size:2rem;top:-1rem}.fs-70{font-size:4.375rem;line-height:6.015625rem}.fs-70 sup{font-size:2.9166666667rem;top:-1.4583333333rem}.fs-76{font-size:4.75rem;line-height:6.53125rem}.fs-76 sup{font-size:3.1666666667rem;top:-1.5833333333rem}@media(min-width:992px){.fs-lg-8{font-size:.5rem;line-height:.6875rem}.fs-lg-10{font-size:.625rem;line-height:.859375rem}.fs-lg-12{font-size:.75rem;line-height:1.03125rem}.fs-lg-14{font-size:.875rem;line-height:1.203125rem}.fs-lg-16{font-size:1rem;line-height:1.375rem}.fs-lg-18{font-size:1.125rem;line-height:1.546875rem}.fs-lg-20{font-size:1.25rem;line-height:1.71875rem}.fs-lg-24{font-size:1.5rem;line-height:2.0625rem}.fs-lg-30{font-size:1.875rem;line-height:2.578125rem}.fs-lg-36{font-size:2.25rem;line-height:3.09375rem}.fs-lg-40{font-size:2.5rem;line-height:3.4375rem}.fs-lg-48{font-size:3rem;line-height:4.125rem}.fs-lg-70{font-size:4.375rem;line-height:6.015625rem}.fs-lg-76{font-size:4.75rem;line-height:6.53125rem}}.mt-8{margin-top:.5rem}.mt-12{margin-top:.75rem}.mt-14{margin-top:.875rem}.mt-16{margin-top:1rem}.mt-18{margin-top:1.125rem}.mt-20{margin-top:1.25rem}.mt-24{margin-top:1.5rem}.mt-34{margin-top:2.125rem}.mt-36{margin-top:2.25rem}.mt-40{margin-top:2.5rem}.mt-48{margin-top:3rem}.mt-60{margin-top:3.75rem}.mt-64{margin-top:4rem}.mb-6{margin-bottom:.375rem}@media(min-width:992px){.mb-lg-6{margin-bottom:.375rem}}.mb-8{margin-bottom:.5rem}@media(min-width:992px){.mb-lg-8{margin-bottom:.5rem}}.mb-12{margin-bottom:.75rem}@media(min-width:992px){.mb-lg-12{margin-bottom:.75rem}}.mb-14{margin-bottom:.875rem}@media(min-width:992px){.mb-lg-14{margin-bottom:.875rem}}.mb-16{margin-bottom:1rem}@media(min-width:992px){.mb-lg-16{margin-bottom:1rem}}.mb-18{margin-bottom:1.125rem}@media(min-width:992px){.mb-lg-18{margin-bottom:1.125rem}}.mb-20{margin-bottom:1.25rem}@media(min-width:992px){.mb-lg-20{margin-bottom:1.25rem}}.mb-24{margin-bottom:1.5rem}@media(min-width:992px){.mb-lg-24{margin-bottom:1.5rem}}.mb-30{margin-bottom:1.875rem}@media(min-width:992px){.mb-lg-30{margin-bottom:1.875rem}}.mb-34{margin-bottom:2.125rem}@media(min-width:992px){.mb-lg-34{margin-bottom:2.125rem}}.mb-36{margin-bottom:2.25rem}@media(min-width:992px){.mb-lg-36{margin-bottom:2.25rem}}.mb-40{margin-bottom:2.5rem}@media(min-width:992px){.mb-lg-40{margin-bottom:2.5rem}}.mb-48{margin-bottom:3rem}@media(min-width:992px){.mb-lg-48{margin-bottom:3rem}}.mb-60{margin-bottom:3.75rem}@media(min-width:992px){.mb-lg-60{margin-bottom:3.75rem}}.mb-64{margin-bottom:4rem}@media(min-width:992px){.mb-lg-64{margin-bottom:4rem}}.pt-6{padding-top:.375rem}@media(min-width:992px){.pt-lg-6{padding-top:.375rem}}.pt-8{padding-top:.5rem}@media(min-width:992px){.pt-lg-8{padding-top:.5rem}}.pt-12{padding-top:.75rem}@media(min-width:992px){.pt-lg-12{padding-top:.75rem}}.pt-14{padding-top:.875rem}@media(min-width:992px){.pt-lg-14{padding-top:.875rem}}.pt-16{padding-top:1rem}@media(min-width:992px){.pt-lg-16{padding-top:1rem}}.pt-18{padding-top:1.125rem}@media(min-width:992px){.pt-lg-18{padding-top:1.125rem}}.pt-20{padding-top:1.25rem}@media(min-width:992px){.pt-lg-20{padding-top:1.25rem}}.pt-24{padding-top:1.5rem}@media(min-width:992px){.pt-lg-24{padding-top:1.5rem}}.pt-30{padding-top:1.875rem}@media(min-width:992px){.pt-lg-30{padding-top:1.875rem}}.pt-34{padding-top:2.125rem}@media(min-width:992px){.pt-lg-34{padding-top:2.125rem}}.pt-36{padding-top:2.25rem}@media(min-width:992px){.pt-lg-36{padding-top:2.25rem}}.pt-40{padding-top:2.5rem}@media(min-width:992px){.pt-lg-40{padding-top:2.5rem}}.pt-48{padding-top:3rem}@media(min-width:992px){.pt-lg-48{padding-top:3rem}}.pt-60{padding-top:3.75rem}@media(min-width:992px){.pt-lg-60{padding-top:3.75rem}}.pt-64{padding-top:4rem}@media(min-width:992px){.pt-lg-64{padding-top:4rem}}.pb-8{padding-bottom:.5rem}.pb-12{padding-bottom:.75rem}.pb-14{padding-bottom:.875rem}.pb-16{padding-bottom:1rem}.pb-18{padding-bottom:1.125rem}.pb-20{padding-bottom:1.25rem}.pb-24{padding-bottom:1.5rem}.pb-34{padding-bottom:2.125rem}.pb-40{padding-bottom:2.5rem}.pb-48{padding-bottom:3rem}.pb-60{padding-bottom:3.75rem}.pb-64{padding-bottom:4rem}.pb-110{padding-bottom:6.875rem}.safety-page sup{font-size:.6em;top:-.4em;font-weight:inherit;line-height:0}.safety-page h1 sup{font-size:.55em!important;top:-.35em!important;font-weight:800!important;position:relative;left:.1em;top:-.65em!important}.safety-page__section{padding-bottom:48px}.safety-page__table-card{margin-top:36px;border:3px solid #07267d;border-radius:24px;overflow:hidden}.safety-page__table-card--mobile{display:none}@media(max-width:767.98px){.safety-page__table-card--mobile{display:block}.safety-page__table-card:not(.safety-page__table-card--mobile){display:none}}.safety-page__table-wrap{overflow-x:auto}.safety-page__table{width:100%;border-collapse:collapse;font-size:16px;line-height:24px;text-align:center}.safety-page__table td,.safety-page__table th{padding:12px 16px;border:1px solid rgba(7,38,125,.2)}.safety-page__table--mobile{font-size:12px;line-height:16px}.safety-page__table--mobile td,.safety-page__table--mobile th{padding:6px 8px}.safety-page__table-corner{background:#fff;border:none}.safety-page__table-pop{font-size:14px;font-weight:800;text-transform:uppercase;letter-spacing:.5px;color:#07267d;padding:10px 16px}.safety-page__table-pop--ntdt{background:#a8b3d3}.safety-page__table-pop--tdt{background:#c1c8e0}.safety-page__table-sub{font-size:14px;font-weight:700;padding:10px 16px}.safety-page__table-sub--aqvesme{background:#07267d;color:#fff}.safety-page__table-sub--placebo{background:#f0f0f0;color:#07267d}.safety-page__table-label-row td{font-weight:800;font-size:14px;color:#07267d;text-align:left;background:#fff}.safety-page__table-row-label{font-weight:600;text-align:left;color:#07267d;background:#fff}.safety-page__table-cell--aqvesme{background:#eff0f6;color:#07267d;font-weight:600}.safety-page__table-cell--placebo{background:#fff;color:#07267d}.safety-page__table-callout{justify-content:flex-start;align-items:center;padding:16px;background:#fff;border-left:3px solid #07267d;border-right:3px solid #07267d;border-bottom:3px solid #07267d;border-bottom-left-radius:24px;border-bottom-right-radius:24px;max-width:55%;margin-left:auto;margin-right:100px}.safety-page__table-callout--mobile{display:none}@media(max-width:767.98px){.safety-page__table-callout--mobile{display:block;max-width:85%;padding:10px;margin-right:auto}.safety-page__table-callout:not(.safety-page__table-callout--mobile){display:none}}.safety-page__table-callout p{color:#b4004b;font-size:18px;font-weight:800;line-height:24px;margin:0;text-align:center}@media(max-width:767.98px){.safety-page__table-callout p{font-size:12px;line-height:14px}}.safety-page__footnotes{margin-top:24px}.safety-page__rems-section{background:#d2e1ed;padding:10px 0 48px}.safety-page__rems-card{background:#fff;border-radius:24px;border:3px solid #07267d;padding:48px;margin-top:24px}@media(max-width:767.98px){.safety-page__rems-card{padding:24px}}.safety-page__rems-heading{color:#b4004b;font-size:24px;font-weight:800;line-height:32px;margin-bottom:24px}@media(max-width:767.98px){.safety-page__rems-heading{font-size:20px;line-height:28px}}.safety-page__rems-list{padding-left:16px;margin-left:0;margin-bottom:0}.safety-page__rems-list li{color:#404044;font-size:18px;line-height:24px;margin-bottom:12px}.safety-page__rems-list li::marker{color:#b4004b}@media(max-width:767.98px){.safety-page__rems-list li{font-size:16px;line-height:22px}}.safety-page__rems-sublist{padding-left:24px;margin-top:8px;list-style-type:circle}.safety-page__rems-sublist li{margin-bottom:6px}.safety-page__rems-abbrev{color:#404044;font-size:14px;margin-top:16px;margin-bottom:24px}.safety-page__red-bold{color:#b4004b;font-weight:800}.safety-page__monitoring-title{margin-top:24px;color:#07267d;font-size:24px;font-weight:800;line-height:32px;margin-bottom:24px}@media(max-width:767.98px){.safety-page__monitoring-title{font-size:20px;line-height:28px}}.safety-page__monitoring-image img{max-width:100%;height:auto}.safety-page__monitoring-image--desktop{display:block}@media(max-width:767.98px){.safety-page__monitoring-image--desktop{display:none}}.safety-page__monitoring-image--mobile{display:none}@media(max-width:767.98px){.safety-page__monitoring-image--mobile{display:block;margin:0 auto}}.safety-page__monitoring-abbrev{color:#404044;font-size:14px;margin-top:16px;margin-bottom:8px}.safety-page__monitoring-footnote{color:#404044;font-size:14px;margin-bottom:0}.safety-page__rems-link{color:#07267d;font-size:18px;font-weight:800;line-height:24px;margin-top:12px}.safety-page__rems-link a{color:#b4004b;font-weight:800;text-decoration:underline}@media(min-width:768px){.safety-page__rems-link a{display:inline-flex}}.safety-page__rems-link a{align-items:center;gap:4px}.safety-page__rems-link a:hover{opacity:.8}@media(max-width:767.98px){.safety-page__rems-link{font-size:16px}}.safety-page__external-icon{width:16px;height:16px}.safety-page__cta-section{padding:48px 0}.safety-page__cta-cards{display:flex;gap:48px}.safety-page__cta-cards a{width:100%}@media(max-width:767.98px){.safety-page__cta-cards{flex-direction:column;gap:36px}}.safety-page__cta-card{flex:1 1;display:flex;flex-direction:column;align-items:center;justify-content:space-between;gap:24px;padding:36px;border:3px solid #07267d;border-radius:24px;text-align:center}@media(max-width:767.98px){.safety-page__cta-card{padding:24px}}.safety-page__cta-text{color:#b4004b;font-size:28px;font-weight:800;line-height:36px;margin:0}@media(max-width:767.98px){.safety-page__cta-text{font-size:24px;line-height:32px}}.safety-page__disclaimer{padding-bottom:24px}.safety-page__disclaimer p{color:#404041;font-size:14px;font-weight:500;margin:0}.safety-page__references{padding-bottom:48px}